The Harter Lab

Comparative Red Blood Cell Physiology

List of peer-reviewed Publications:

supervised student, *indicates equal contribution by authors

  1. Harter, T. S. (Under Review). Fish red blood cells. In: Handbook of Red Blood Cells. Eds: Kaestner L. and Bogdanova A. Y. Springer Nature, Berlin. (Postdoc)
  2. Kwan, G. T., Clifford, A. M., Prime, K. J., Harter, T. S. and Tresguerres, M. (2024). Gill ionocyte remodeling mediates blood pH regulation in rockfish (Sebastes diploproa) exposed to environmentally relevant hypercapnia. Physiological Genomics. doi.org/10.1152/physiolgenomics.00057.2024 (Postdoc)
  3. Harter, T. S. and Scott, G. (2024). Linking red blood cell functional phenotypes to environmental tolerance in high-altitude adapted deer mice. Physiology 39, 649. doi.org/10.1152/physiol.2024.39.S1.649. (Postdoc)
  4. Harter T. S., Smith E.A., Salmerón C., Thies A. B., Delgado B., Wilson R. W., Tresguerres M. (2024) Soluble adenylyl cyclase is an acid-base sensor in rainbow trout red blood cells that regulates intracellular pH and haemoglobin–oxygen binding. Acta Physiologica. doi.org/10.1111/apha.14205 (Postdoc)
  5. Harter, T. S., Dichiera A.M, Esbaugh, A. J. (2024) The physiological significance of plasma accessible carbonic anhydrase in the respiratory systems of fishes. J. Comp. Physol. B. special issue on „The Multifunctional fish gill“. doi.org/10.1007/s00360-024-01562-4 (Postdoc)
  6. Harter, T. S. and Nikinmaa M. (2024). Erythrocyte function. In “Encyclopedia of Fish Physiology. Reference Module in Life Sciences.” 2nd Edition. Eds.: Alderman S. L., Gillies T. E.. Elsevier. Hardback ISBN: 9780323908016. (Postdoc)
  7. Harter, T. S., Smith, E. A. and Tresguerres, M. (2023). A novel perspective on the evolutionary loss of plasma-accessible carbonic anhydrase at the teleost gill. J. Exp. Biol. 226, jeb246016. doi.org/10.1242/jeb.246016 (Postdoc)
  8. Shartau, R. B., Harter, T. S., Baker, D. W., Aboagye, D. L., Allen, P. J., Val, A. L., Crossley, D. A., Kohl, Z. F., Hedrick, M. S., Damsgaard, C., Brauner C. J. (2022). Acute CO2 tolerance in fishes is associated with air breathing but not the Root effect, red cell βNHE, or habitat. CBPA: 274, 111304. doi.org/10.1016/j.cbpa.2022.111304 (Postdoc)
  9. Harter T. S., Damsgaard C., Regan M. D. (2022). Linking environmental salinity to respiratory phenotypes and metabolic rate in fishes: a data mining and modelling approach. Invited Review. J. Exp. Biol. 225, jeb243421. doi.org/10.1242/jeb.243421 (Postdoc)
  10. Harter, T. S.,Clifford, A. M., Tresguerres, M. (2021) Adrenergically induced translocation of red blood cell β-adrenergic sodium-proton exchangers has ecological relevance for hypoxic and hypercapnic white seabass. Am. J. Physiol. Regul. Integr. Comp. Physiol. doi.org/10.1152/ajpregu.00175.2021 (Postdoc)
  11. Gallagher E. J., Harter T. S, Brauner C. J. (2021). The ontogeny of Na+ balance during rapid smoltification in pink salmon (Oncorhynchus gorbuscha). J. Comp. Physiol. B. doi.org/10.1007/s00360-020-01309-x (Postdoc)
  12. Gallagher E. J., Harter T. S, Wilson J. M., Brauner C. J (2021). The ontogeny of Na+ uptake in larval rainbow trout reared in waters of different Na+ content. J. Comp. Physiol. B. doi.org/10.1007/s00360-020-01311-3 (Postdoc)
  13. Damsgaard, C., Lauridsen, H., Harter, T., Kwan, G., Thomsen, J., Funder, A., Supuran, C., Tresguerres, M., Matthews, P. and Brauner, C. (2021). Active Blood Acidification Greatly Enhances Oxygen Supply to the Teleost Retina. The FASEB Journal 35. doi.org/10.1096/fasebj.2021.35.S1.01833 (Postdoc)
  14. Harter, T. S. and Brauner, C. J. (2021). Teleost red blood cells actively enhance the passive diffusion of oxygen that was discovered by August Krogh. Comp. Biochem. Physiol., A: Mol. Integr. Physiol. 253, 110855. doi.org/10.1016/j.cbpa.2020.110855 (Postdoc)
  15. Salmerón, C., Harter, T. S., Kwan, G. T., Roa, J. N., Blair, S. D., Rummer, J. L., Shiels, H. A., Goss, G. G., Wilson, R. W. and Tresguerres, M. (2021). Molecular and biochemical characterization of the bicarbonate-sensing soluble adenylyl cyclase from a bony fish, the rainbow trout Oncorhynchus mykiss. Interface Focus 11, 20200026. doi.org/10.1098/rsfs.2020.0026 (Postdoc)
  16. Damsgaard, C., Lauridsen, H., Harter, T. S., Kwan, G. T., Thomsen, J. S., Funder, A. M., Supuran, C. T., Tresguerres, M., Matthews, P. G. and Brauner, C. J. (2020). A novel acidification mechanism for greatly enhanced oxygen supply to the fish retina. eLife 9, e58995. doi.org/10.7554/eLife.58995 (Postdoc)
  17. Tresguerres M., Clifford A. M., Harter T. S., Roa J. N., Thies A. B., Yee D. P., Brauner C. J. (2020) Evolutionary links between intra- and extracellular acid-base regulation in fish and other aquatic animals. J. Exp. Zool. doi.org/10.1002/jez.2367 (Postdoc)
  18. Shartau, R. B., Baker, D. W., Harter, T. S., Aboagye, D. L., Allen, P. J., Val, A. L., Crossley, D. A., Kohl, Z. F., Hedrick, M. S., Damsgaard, C., Brauner C. J. (2020). Preferential intracellular pH regulation is a common trait amongst fishes exposed to high environmental CO2. J. Exp. Biol. 223 doi.org/10.1242/jeb.208868 (PhD)
  19. McMillan, O. J. L., Dichiera, A. M., Harter, T. S., Wilson, J. M., Esbaugh, A. J. and Brauner, C. J. (2019). Blood and Gill Carbonic Anhydrase in the Context of a Chondrichthyan Model of CO2 Excretion. Physiol. Biochem. Zool. 92, 554–566. doi.org/10.1086/705402 (PhD)
  20. Harter T. S., Zanuzzo F. S., Supuran C. T., Gamperl A. K. and Brauner C. J. (2019). The importance of plasma accessible carbonic anhydrase for enhancing tissue oxygen extraction during exercise in Atlantic salmon. Proc. Roy. Soc. B, 286, 1903:20190339. doi.org/10.1098/rspb.2019.0339 (PhD)
  21. Ferreira, M. S., Wood, C. M., Harter, T. S., Pont, G. D., Val, A. L. and Matthews, P. G. D. (2019). Metabolic fuel use after feeding in the zebrafish (Danio rerio): a respirometric analysis. J. Exp. Biol. 222 (4): jeb194217. doi.org/10.1242/jeb.194217 (PhD)
  22. Harter, T. S., Sackville, M., Wilson, J., Metzger, D., Egginton, S., Esbaugh, A., Farrell, A. and Brauner, C. (2018). A solution to Nature’s haemoglobin knockout: a plasma-accessible carbonic anhydrase catalyses CO2 excretion in Antarctic icefish gills. J. Exp. Biol., 221 (22): jeb190918. doi.org/10.1242/jeb.190918 (PhD). Winner of the JEB Outstanding Paper Prize 2018
  23. Harter T. S., May A., Federspiel W. J, Supuran C. T. and Brauner C. J. (2018). The time-course of red blood cell intracellular pH recovery following short-circuiting in relation to venous transit times in rainbow trout, Oncorhynchus mykiss. Am. J. Physiol. Regul. Integr. Comp. Physiol. 315 (2), R397-R407. doi.org/10.1152/ajpregu.00062.2018 (PhD)
  24. Shu J. J., Harter T. S., Morrison P. R., Brauner C. J. (2018). Enhanced hemoglobin-oxygen unloading in migratory salmonids. J Comp Physiol B 188, 409–419. doi.org/10.1007/s00360-017-1139-9 (PhD)
  25. Harter, T. S. and Brauner, C. J.(2017). The O2 and CO2 transport system in teleosts and the specialized mechanisms that enhance Hb-O2 unloading to tissues. In Fish Physiology. The Cardiovascular System: Morphology, Control and Function, vol. 36 B: Phenotypic and Physiological Responses (eds. A. K. Gamperl T. E. Gillis A. P. Farrell and C. J. Brauner), pp. 1-106. New York: Academic Press. doi.org/10.1016/bs.fp.2017.09.001 (PhD)
  26. Brauner, C. J. and Harter, T. S. (2017). Beyond just hemoglobin: Red blood cell potentiation of hemoglobin-oxygen unloading in fish. J. Appl. Physiol. 123 (4), 935-941. doi.org/10.1152/japplphysiol.00114.2017 (PhD)
  27. Harter T. S., Brauner C. J. and Mathews P. G. D. (2017). A novel technique for the precise measurement of CO2 production rate in small aquatic organisms as validated on Aeshnid dragonfly nymphs. J. Exp. Biol. 220: 964-968. doi.org/10.1242/jeb.150235 (PhD)
  28. Brauner, C.J., Harter, T.S. and Rummer, J.L. (2017). Gas transport and exchange: interaction between O2 and CO2 exchange. In “Encyclopedia of Fish Physiology. Reference Module in Life Sciences.” Elsevier. doi.org/10.1016/B978-0-12-809633-8.03114-9 (PhD)
  29. Alderman S. L.*, Harter T. S.*, Wilson J. M., Supuran C. T., Farrell A. P., and Brauner C. J. (2016). Evidence for a plasma-accessible carbonic anhydrase in the lumen of salmon heart that may enhance oxygen delivery to the myocardium. J. Exp. Biol. 219 (5), 719-724. doi.org/10.1242/jeb.130443 (PhD)
  30. Gillis T.*, Regan M.*, Cox G., Harter T, Brauner C., Richards J., Farrell A. (2015) Characterizing the metabolic capacity of the anoxic hagfish heart. J. Exp. Biol. 218 (23), 3754-3761. doi.org/10.1242/jeb.125070 (PhD)
  31. Harter T. S., Reichert M., Brauner C. J., Milsom W. K. (2015) Validation of the i-STAT and HemoCue systems for the analysis of blood parameters in the bar-headed goose, Anser indicus. Cons. Physiol. 3 (1) cov021. doi.org/10.1093/conphys/cov021 (PhD)
  32. Harter T. S., Morrison P. R., Mandelman J. W., Rummer J. L., Farrell A. P., Brill R. W., Brauner C. J. (2015) Validation of the i-STAT system for the analysis of blood gases and acid–base status in juvenile sandbar shark (Carcharhinus plumbeus). Cons. Physiol. 3 (1) cov002. doi.org/10.1093/conphys/cov002 (PhD)
  33. Harter T. S., R. B. Shartau, C. J. Brauner, A. P. Farrell (2014). Validation of the i-STAT system for the analysis of blood parameters in fish Cons. Physiol. 2 (1) cou037. doi.org/10.1093/conphys/cou037 (PhD)
  34. Harter T. S., R. B. Shartau, D. W. Baker, D.C. Jackson, A. L. Val and C. J. Brauner (2014). Preferential regulation of intracellular pH represents a general pattern of pH homeostasis in the armoured catfish, Pterygoplichthys pardalis. J Comp Physiol B 184 (6), 709-718. doi.org/10.1007/s00360-014-0838-8 (PhD)
  35. Harter T. S., Leon T. N. Heinsbroek, Johan W. Schrama (2014). The source of dietary non-protein energy affects in vivo protein digestion in African catfish (Clarias gariepinus). Aqua. Nutr. 21 (5), 569–577. doi.org/10.1111/anu.12185 (MSc)
  36. Harter T. S., J. A. J. Verreth, L. T. H. Heinsbroek and J. W. Schrama (2013). Isoenergetic replacement of fat by starch in diets for African catfish (Clarias gariepinus): Effect on water fluxes in the gastro-intestinal tract. PLoS ONE 8 (1), e55245. doi.org/10.1371/journal.pone.0055245 (MSc)
  37. Harter T. S., P. Bossier, J. Verreth, S. Bodé, D. Ha, A.-E. Debeer, N. Boon, P. Boeckx, W. Vyverman, N. Nevejan (2012). Carbon and nitrogen mass balance during flue gas treatment with Dunaliella salina cultures. J. Appl. Phycol. 25, 359-368. doi.org/10.1007/s10811-012-9870-9 (MSc)
  38. Harter T. S., F. Buhrke, V. Kumar, U. Focken, H. P. S. Makkar and K. Becker (2011). Substitution of fish meal by Jatropha curcas kernel meal: Effects on growth performance and body composition of white-leg shrimp (Litopenaeus vannamei). Aqua. Nutr. 17(5): 542-548. doi.org/10.1111/j.1365-2095.2010.00845.x (BSc)